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anygui - The goal of this project is to create an easy-to-use, simple, and generic module for making graphical user interfaces in Python. [Open Source, MIT license]
The Dabo Framework - A 3-tier, cross-platform application development framework, written in Python atop the wxPython GUI toolkit. [Open source, MIT license]
FXPy - Provides an interface to the FOX GUI library. [Open Source, LGPL]
Pmw - Python meta widgets is a toolkit for building high-level compound widgets in Python using the Tkinter module. [Open Source, MIT license]
pygame - A set of Python extension modules designed for writing games. The core of pygame is wrapped on top of the SDL library. [Open Source, LGPL]
PyGTK - Python bindings for the GTK widget set. [Open Source, LGPL]
PyKDE - Python bindings for the KDE desktop environment. [Open Source, BSD-like]
PyQt - Contains Python bindings for the Qt GUI toolkit. [Open Source, BSD-like]
Python X Library - Pure Python interface to X Window system. [Open Source, GPL]
PythonCard - A software construction kit built in, and using, Python. Its purpose is to allow you to easily and quickly build graphical applications. [Open Source, Python license]
Tix - The Tk Interface eXtension is a set of GUI components that enhance the appearance and functionality of your Tkinter applications. [Open Source, BSD-like]
Tix Applications Framework - Tixapps applications are a suite of development applications that run with Tk/Tcl or Python using the Tix widget set. Applications currently included are: tixinspect - an inspector for Tix/Tk applications; tixdebug - a debugger to work with tixinspect; and tixinfo - an information browser for GNU documentation.
Tkinter3000 Widget Construction Kit - Tkinter3000 is a Widget Construction Kit that allows you to write new Tkinter widgets in Python using Mixins. [Open Source, BSD-like]
wxPython - A popular cross-platform Python GUI toolkit for Windows and Unix with native look and feel on each platform. [Open Source, LGPL]
xdialog - A wrapper for the Xdialog program that encapsulates the details of calling Xdialog and getting return values. [Open Source, LGPL]